# Tag Archives: optimization

## Modeling Response Surfaces Using Factorial Designs

In many cases the underlying theoretical relationship between the response and its factors is unknown. We can still develop a model of the response surface if we make some reasonable assumptions about the underlying relationship between the factors and the … Continue reading

## Simplex Optimization

One strategy for improving the efficiency of a searching algorithm is to change more than one factor at a time. A convenient way to accomplish this when there are two factors is to begin with three sets of initial factor … Continue reading

## One-Factor-at-a-Time Searching Algorithm

A simple algorithm for optimizing the response for a system is to adjust independently each factor. Consider a response that depends on two factors. We begin by optimizing the response for one factor by increasing or decreasing its value, holding … Continue reading

## Using a Solvent Triangle to Optimize an HPLC Separation

One strategy for finding the best mobile phase for an HPLC separation is to use the solvent triangle, which allows us to explore a broad range of mobile phases with just seven experiments. We begin by adjusting the amount of acetonitrile … Continue reading

Posted in Illustration
Tagged chromatography, HPLC, liquid chromatography, optimization, separation, solvent triangle
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